The A14 eastbound remains shut between J33 and J35 after a fatal multi-vehicle crash.
Emergency services were called to the scene near Horningsea just before 9.30pm last night.
A person in a car died and three others suffered serious injuries in the collision.
A 38-year-old lorry driver from Cambridge has been arrested on suspicion of causing death by dangerous driving.
Cambridgeshire Police say a complex investigation is under way and the road may not reopen before early afternoon.
